Introduction MC has since been prescribed for a wide variety of indications including refractory symptoms experienced by patients in cancer care settings such as insomnia, chemotherapy-induced nausea and vomiting and pain. The objective of this study is to explore the effectiveness, compliance and patient acceptability of MC for symptom management. Methods Semi-structured interviews were conducted with patients presenting with a valid prescription for MC at a Sydney metropolitan cancer treatment centre, audio-recorded and transcribed verbatim. Descriptive statistical analysis was performed to describe demographic information and study outcomes including patient compliance and MC effectiveness. Tests for independence were also undertaken to investigate any impacts which demographic factors had on study outcomes. Thematic analysis guided, by a Grounded Theory Approach, was performed to identify themes which were considered facilitators and barriers for patient compliance and acceptability of MC use. Results and Discussion Most patients (73%, n=11/15) were compliant and found MC effective in managing indicated symptoms ‘all the time’. Overall, patients had positive experiences with using MC as it provided symptom relief and reduced other medications used. Four themes which emerged included personal factors, disease-related factors, medication-related factors, and accessibility factors. The most frequently reported subtheme was legal concerns. No statistically significant results were found between compliance and demographic factors. However, there was statistically significant associations between compliance which favoured reliable symptom relief (p <.001) and MC formulation (p=0.026). Conclusion This study identified barriers that were not reported previously and highlighted the importance of patient education from healthcare professionals on MC regarding side effects, addiction, forgetfulness, and unpleasant taste. Most patients who considered vehicle use as an essential activity were concerned about the legality of driving. Law reforms and patient education may be necessary to facilitate the safe and effective use of MC and improved symptom control overall for patients with cancer.